Histamine Releasing Urticaria Screen

Three reasons the Histamine Releasing Urticaria Test is right for you

• This test helps identify whether your immune system is releasing histamine in response to certain triggers, which can cause chronic hives
• It is particularly useful for diagnosing chronic spontaneous urticaria or unexplained allergic reactions
• Results allow your healthcare provider to tailor treatment plans, including antihistamines or other targeted therapies

What is the Histamine Releasing Urticaria Test?

The Histamine Releasing Urticaria Test evaluates your blood for abnormal histamine release by immune cells. Histamine is a chemical responsible for inflammation, itching, and swelling in allergic reactions. Overactive histamine release can lead to chronic or recurrent hives (urticaria).

This test is often recommended for:

• Individuals with persistent or unexplained hives
• Patients who do not respond to standard allergy or antihistamine treatments
• People suspected of having autoimmune or immune-mediated urticaria
• Those needing detailed assessment to guide specialised treatment

What are the symptoms of abnormal histamine release?

Excessive histamine release can cause a range of symptoms, including:

• Red, raised, itchy welts or hives on the skin
• Swelling of lips, eyelids, or other areas (angioedema)
• Burning, stinging, or tingling sensations on the skin
• Symptoms that appear spontaneously or after exposure to potential triggers
• Chronic or recurrent episodes lasting weeks to months

How does the Histamine Releasing Urticaria Test work?

A blood sample is taken and analysed to measure the amount of histamine released by immune cells. Abnormal or excessive release indicates a higher likelihood of histamine-driven urticaria. The results help your clinician understand the underlying cause of your symptoms and guide a personalised treatment plan.

What can I expect at my appointment?

Your appointment involves a standard blood draw performed by a trained healthcare professional. The procedure is quick and minimally invasive.

Once analysed, results are typically available within 3 weeks. You will receive a report showing whether your immune cells are releasing histamine abnormally, along with recommendations for further investigation or treatment.

Are there any risks with this test?

This is a routine blood test and is considered very safe. Most people experience only mild discomfort at the needle site.

Minor bruising or tenderness may occasionally occur. Serious complications are extremely rare. Seek medical advice if you feel unwell after the test.

How do I schedule my appointment?

To book your appointment, click the “Book Your Appointment” button at the top of the page. Select your preferred clinic, date, and time, and we will provide any special instructions for your blood sample collection.