MTHFR (Methylenetetrahydrofolate reductase)

Three reasons the MTHFR genetic test is right for you

• This test identifies common genetic variants that can affect folate metabolism and methylation pathways
• It may help explain unexplained cardiovascular risk, pregnancy complications, or elevated homocysteine levels
• Results support personalised nutritional and clinical management where MTHFR variants are present

What is the MTHFR – common C677T + A1298C variants test?

This genetic test analyses two common variants of the MTHFR (methylenetetrahydrofolate reductase) gene: C677T and A1298C. These variants can affect how efficiently your body processes folate and regulates homocysteine levels, which are important for cardiovascular health, neurological function, and pregnancy outcomes.

This test is often recommended for:

• Individuals with elevated homocysteine levels
• Those with a personal or family history of cardiovascular disease
• Women with recurrent pregnancy loss or pregnancy complications
• People with suspected folate metabolism or methylation issues

What are the symptoms or concerns linked to MTHFR variants?

Many people with MTHFR variants may have no symptoms. When present, possible concerns include:

• Elevated homocysteine levels
• Increased risk of blood clots or cardiovascular disease
• Pregnancy complications, including miscarriage
• Fatigue or neurological symptoms in some individuals
• Reduced response to standard folic acid supplementation

How does the MTHFR genetic test work?

A blood sample is collected and analysed using molecular techniques to detect the presence of the C677T and A1298C variants in the MTHFR gene. The results show whether you carry none, one, or two copies of these variants, helping your clinician assess any potential impact on folate metabolism and related health risks.

What can I expect at my appointment?

Your appointment involves a simple blood draw using an EDTA (lavender-top) tube. The sample is taken by a trained healthcare professional and the procedure is quick and safe.

Results are typically available within 5 days. Your report will indicate whether the MTHFR C677T and/or A1298C variants are present, along with interpretive information to support clinical or nutritional decision-making.

Are there any risks with this test?

This is a routine blood test and carries minimal risk. Most people experience only brief discomfort during the blood draw.

Mild bruising or tenderness at the puncture site may occur. Serious complications are extremely rare.

How do I schedule my appointment?

To book your appointment, click the “Book Your Appointment” button at the top of the page. Choose your preferred clinic, date, and time, and we will guide you through the booking process.